Publications
2023
Mikhael A, Hardie D, Smith D, Pětrošová H, Ernst RK, Goodlett DR (2023) Structural Elucidation of Intact Rough-type Lipopolysaccharides Using Field Asymmetric Ion Mobility Spectrometry and Kendrick Mass Defect Plots. Anal Chem. PMID: 37943784
Scott AJ, Smith AA, Heeren RMA, Pal U, Ernst RK (2023) Characterization of spatial lipidomic signatures in tick-bitten guinea pig skin as a model for host-vector-pathogen interaction profiling. mSystems. PMID: 37874165
Tomlinson KL, Chen YT, Junker A, Urso A, Wong Fok Lung T, Ahn D, Hofstaedter CE, Baskota SU, Ernst RK, Prince A, Riquelme SA (2023) Ketogenesis promotes tolerance to Pseudomonas aeruginosa pulmonary infection. Cell Metab. PMID: 37793346
Da Silva JT, Hernandez-Rojas LG, Mekonen HK, Hanson S, Melemedjian O, Scott AJ, Ernst RK, Seminowicz DA, Traub RJ. (2023) Sex differences in visceral sensitivity and brain activity in a rat model of comorbid pain: a longitudinal study. Pain. PMID: 37756658
Lu T, Das S, Howlader DR, Jain A, Hu G, Dietz ZK, Zheng Q, Ratnakaram SSK, Whittier SK, Varisco DJ, Ernst RK, Picking WD, Picking WL. (2023) Impact of the TLR4 agonist BECC438 on a novel vaccine formulation against Shigella spp. Front Immunol. PMID: 37744341
Scott AJ, Ellis SR, Hofstaedter CE, Heeren RMA, Ernst RK. (2023) Spatial lipidomics reveals biased phospholipid remodeling in acute Pseudomonas lung infection. iScience. PMID: 37680478
O'Meara TR, Nanishi E, McGrath ME, Barman S, Dong D, Dillen C, Menon M, Seo HS, Dhe-Paganon S, Ernst RK, Levy O, Frieman MB, Dowling DJ. (2023) Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance. J Allergy Clin Immunol. PMID: 37595760
Hu G, Varisco DJ, Das S, Middaugh CR, Gardner F, Ernst RK, Picking WL, Picking WD. (2023) Physicochemical characterization of biological and synthetic forms of two lipid A-based TLR4 agonists. Heliyon. PMID: 37483830
Smith RD, Johnson JK, Ernst RK. (2023) Comparison of 3 diagnostic platforms for identification of bacteria and yeast from positive blood culture bottles. Diagn Microbiol Infect Dis. PMID: 37478505
Das S, Howlader DR, Lu T, Whittier SK, Hu G, Sharma S, Dietz ZK, Ratnakaram SSK, Varisco DJ, Ernst RK, Picking WD, Picking WL. (2023) Immunogenicity and protective efficacy of nanoparticle formulations of L-SseB against Salmonella infection. Front Immunol. PMID: 37457702
Lee KS, Rader NA, Miller-Stump OA, Cooper M, Wong TY, Shahrier Amin M, Barbier M, Bevere JR, Ernst RK, Heath Damron F. (2023) Intranasal VLP-RBD vaccine adjuvanted with BECC470 confers immunity against Delta SARS-CoV-2 challenge in K18-hACE2-mice. Vaccine. PMID: 37407405
Chandler CE, Hofstaedter CE, Hazen TH, Rasko DA, Ernst RK. (2023) Genomic and Functional Characterization of Longitudinal Pseudomonas aeruginosa Isolates from Young Patients with Cystic Fibrosis. Microbiol Spectr. PMID: 37358436
Pětrošová H, Mikhael A, Culos S, Giraud-Gatineau A, Gomez AM, Sherman ME, Ernst RK, Cameron CE, Picardeau M, Goodlett DR. Front Microbiol. (2023) Lipid A structural diversity among members of the genus Leptospira. Front Micro. PMID: 37303810
Yang H, Sherman ME, Koo CJ, Treaster LM, Smith JP, Gallaher SG, Goodlett DR, Sweet CR, and Ernst RK. (2023) Structure Determination of Lipid A with Multiple Glycosylation Sites by Tandem MS of Lithium-Adducted Negative Ions. J Am Soc Mass Spectrom. Accepted for publication May 15. PMID: 37184080
Marrujo SA, Hubble VB, Yang J, Wang M, Nemeth AM, Barlock SL, Juarez D, Smith RD, Melander RJ, Ernst RK, Chang M, Melander C (2023) Dimeric 2-aminoimidazoles are highly active adjuvants for gram-positive selective antibiotics against Acinetobacter baumannii. Eur J Med Chem. PMID: 37023677
Howlader DR, Das S, Lu T, Mandal RS, Hu G, Varisco DJ, Dietz ZK, Ratnakaram SSK, Ernst RK, Picking WD, Picking WL (2023) A protein subunit vaccine elicits a balanced immune response that protects against Pseudomonas pulmonary infection. NPJ Vaccines. PMID: 36918600
2022
Li H, Mattingly AE, Smith RD, Melander RJ, Ernst RK, Melander C (2022) 6-Bromoindirubin-3'-oxime derivatives are highly active colistin adjuvants against Klebsiella pneumoniae. RSC Med Chem. PMID: 36846374
Nanishi E, Borriello F, Seo HS, O'Meara TR, McGrath ME, Saito Y, Chen J, Diray-Arce J, Song K, Xu AZ, Barman S, Menon M, Dong D, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Baden LR, Ernst RK, Dillen C, Yu J, Chang A, Hilgers L, Platenburg PP, Dhe-Paganon S, Barouch DH, Ozonoff A, Zanoni I, Frieman MB, Dowling DJ, Levy O. (2022) Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice. NPJ Vaccines. PMID: 36788219
Ha M, Ngaage LM, Smith RD, Izac JR, Kim PC, Singh D, Slezak S, Ernst RK, Harro J, Rasko YM. (2022) An In Vitro Model of the Efficacy of Breast Implant Irrigant Solutions Against Gram-Negative Infections. Ann Plast Surg. PMID: 36416700
Blackwood CB, Mateu-Borrás M, Sen-Kilic E, Pyles GM, Miller SJ, Weaver KL, Witt WT, Huckaby AB, Kang J, Chandler CE, Ernst RK, Heath Damron F, Barbier M. (2022) Bordetella pertussis whole cell immunization protects against Pseudomonas aeruginosa infections. NPJ Vaccines. PMID: 36357402
Onyedibe KI, Nemeth AM, Dayal N, Smith RD, Lamptey J, Ernst RK, Melander RJ, Melander C, Sintim HO (2023) Re-sensitization of Multidrug-Resistant and Colistin-Resistant Gram-Negative Bacteria to Colistin by Povarov/Doebner-Derived Compounds. ACS Infect Dis. PMID: 36651182
Haupt R, Baracco L, Harberts EM, Loganathan M, Kerstetter LJ, Krammer F, Coughlan L, Ernst RK, Frieman MB (2023) Enhancing the protection of influenza virus vaccines with BECC TLR4 adjuvant in aged mice Sci Rep. PMID: 36639569 23. Välikangas T, Suomi T, Chandler CE, Scott AJ, Tran BQ, Ernst RK, Goodlett DR, Elo LL. (2022) Benchmarking tools for detecting longitudinal differential expression in proteomics data allows establishing a robust reproducibility optimization regression approach. Nat Commun. PMID: 36550114
Yang H, Smith RD, Sumner KP, Goodlett DR, Johnson JK, Ernst RK. (2023) A Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry Direct-from-Urine-Specimen Diagnostic for Gram-Negative Pathogens. Microbiol Spectr. PMID: 36255333
Sherman M, Smith, R, Gardner M, Goodlett D, and Ernst RK (2022) A sensitive GC-MS method for quantitation of lipid A backbone components and terminal phosphate modifications. Journal of the American Society for Mass Spectrometry. PMID: 36326685
Montoya NR, Porsch EA, Muñoz VL, Muszyński A, Vlach J, Hahn DK, Azadi P, Sherman M, Yang H, Chandler CE, Ernst RK, St Geme JW 3rd (2022) Surface Anchoring of the Kingella kingae Galactan Is Dependent on the Lipopolysaccharide O-Antigen. mBio. e0229522. PMID: 36069736
Nanishi E, McGrath ME, O'Meara TR, Barman S, Yu J, Wan H, Dillen CA, Menon M, Seo HS, Song K, Xu AZ, Sebastian L, Brook B, Bosco AN, Borriello F, Ernst RK, Barouch DH, Dhe-Paganon S, Levy O, Frieman MB, Dowling DJ (2022) mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant. Commun Biol. 6;5(1):790. PMID: 35933439
Harberts EM, Grubaugh D, Akuma DC, Shin S, Ernst RK, Brodsky IE (2022) Position-Specific Secondary Acylation Determines Detection of Lipid A by Murine TLR4 and Caspase-11. Infect Immun. e0020122. PMID: 35862717
Alexander-Floyd J, Bass AR, Harberts EM, Grubaugh D, Buxbaum JD, Brodsky IE, Ernst RK, Shin S. (2022) Lipid A Variants Activate Human TLR4 and the Noncanonical Inflammasome Differently and Require the Core Oligosaccharide for Inflammasome Activation. Infect Immun. e0020822. PMID: 35862709
Nordstrom HR, Evans DR, Finney AG, Westbrook KJ, Zamora PF, Hofstaedter CE, Yassin MH, Pradhan A, Iovleva A, Ernst RK, Bomberger JM, Shields RK, Doi Y, Van Tyne D (2022) Genomic characterization of lytic bacteriophages targeting genetically diverse Pseudomonas aeruginosa clinical isolates. iScience. 25(6):104372. PMID: 35620437
Yang H, Smith RD, Chandler CE, Johnson J, Jackson SN, Woods AS, Scott AJ, Goodlett DR, and Ernst RK (2022) Lipid A structural determination from a single colony. Analytic Chemistry. PMID: 35576511
Wong Fok Lung T, Charytonowicz D, Beaumont KG, Shah SS, Sridhar SH, Gorrie CL, Mu A, Hofstaedter CE, Varisco D, McConville TH, Drikic M, Fowler B, Urso A, Shi W, Fucich D, Annavajhala MK, Khan IN, Oussenko I, Francoeur N, Smith ML, Stockwell BR, Lewis IA, Hachani A, Upadhyay Baskota S, Uhlemann AC, Ahn D, Ernst RK, Howden BP, Sebra R, and Prince A (2022) Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection. Cell Metab. S1550-4131(22)00097-3. PMID: 35413274
Postolache TT, Upadhyaya SK, Spector AM, Mohyuddin I, Constantine N, Ernst RK, Wadhawan A, Dutra SVO, Dagdag A, Makkar H, Lowry CA, Akram F, Fuchs D, Brenner LA, Groer MW, and Reynolds MA.(2022) Decreasing Tryptophan and Increasing Neopterin Plasma Levels During Pregnancy are Associated with High First Trimester Porphyromonas gingivalis K-Serotype IgG Serointensity in a cohort of Hispanic Women. Curr Top Med Chem. 2022 Apr 4. PMID: 35379151
Bray AS, Smith RD, Hudson AW, Hernandez GE, Young TM, George HE, Ernst RK, and Zafar MA. (2022) MgrB-Dependent Colistin Resistance in Klebsiella pneumoniae Is Associated with an Increase in Host-to-Host Transmission. mBio. 13(2):e0359521. PMID: 35311534
Wong TY, Lee KS, Russ BP, Horspool AM, Kang J, Winters MT, Allison Wolf M, Rader NA, Miller OA, Shiflett M, Izac J, Varisco D, Sen-Kilic E, Cunningham C, Cooper M, Cyphert HA, Barbier M, Martinez I, Bevere JR, Ernst RK, and Damron FH. (2022) Intranasal administration of BReC-CoV-2 COVID-19 vaccine protects K18-hACE2 mice against lethal SARS-CoV-2 challenge. NPJ Vaccines. 7(1):36. PMID: 35288576
Gerster T, Wröbel M, Hofstaedter CE, Schwudke D, Ernst RK, Ranf S, and Gisch N (2022) Remodeling of Lipid A in Pseudomonas syringae pv. phaseolicola In Vitro .Int J Mol Sci. 23(4):1996. PMID: 35216122
Smith RD, McElheny CL, Izac JR, Gardner FM, Chandler CE, Goodlett DR, Doi Y, Johnson JK, and Ernst RK. (2022) A Novel Lipid-Based MALDI-TOF Assay for the Rapid Detection of Colistin-Resistant Enterobacter Species. Microbiol Spectr. Feb 2;10(1):e0144521. PMID: 3510736
2021
Smith RD, Izac JR, Ha M, Yang H, Johnson JK, and Ernst RK. (2021) Rapid identification of mcr-1-positive Escherichia coli from patient urine using a novel lipid-based MALDI-TOF-MS assay. Access Microbiol. 2021 Dec 17;3(12):000309. PMID: 35024564
Yeung WY, Tordik PA, Martinho FC, and Ernst RK. (2021) Positively Charged Polyvinylidene Fluoride Membrane: A Potential Alternative for Absorbent Paper Points in Endodontics. J Endod. 2021 Nov 20:S0099-2399(21)00801-3. PMID: 34813795
Nanishi E, Borriello F, O'Meara TR, McGrath ME, Saito Y, Haupt RE, Seo HS, van Haren SD, Cavazzoni CB, Brook B, Barman S, Chen J, Diray-Arce J, Doss-Gollin S, De Leon M, Prevost-Reilly A, Chew K, Menon M, Song K, Xu AZ, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Sherman AC, Baden LR, Ernst RK, Dillen C, Weston SM, Johnson RM, Hammond HL, Mayer R, Burke A, Bottazzi ME, Hotez PJ, Strych U, Chang A, Yu J, Sage PT, Barouch DH, Dhe-Paganon S, Zanoni I, Ozonoff A, Frieman MB, Levy O, and Dowling DJ. (2021) An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor-binding domain vaccine in aged mice. Sci Transl Med. 2021 Nov 16:eabj5305. PMID: 34783582
Li H, Mattingly AE, Jania LA, Smith R, Melander RJ, Ernst RK, Koller BH, and Melander C (2021) Benzimidazole Isosteres of Salicylanilides Are Highly Active Colistin Adjuvants. ACS Infect Dis. 2021 Dec 10;7(12):3303-3313. PMID: 34752055
Howlander DR, Das S, Lu T, Hu G, Varisco DJ, Dietz ZK, Walton SP, Ratnakaram SSK, Gardner FM, Ernst RK, Picking WD, and Picking WL (2021) Effect of Two Unique Nanoparticle Formulations on the Efficacy of a Broadly Protective Vaccine Against Pseudomonas aeruginosa. Front. Pharmacol., 18 August. PMID: 34483911
Haupt RE, Harberts EM, Kitz RJ, Strohmeier S, Krammer F, Ernst RK, Frieman MB (2021) Novel TLR4 adjuvant elicits protection against homologous and heterologous Influenza A infection. Vaccine, Accepted for publication 7/21. PMID: 34362603
Gauthier AE, Chandler CE, Poli V, Gardner FM, Tekiau A, Smith R, Bonham KS, Cordes EE, Shank TM, Zanoni I, Goodlett DR, Biller SJ, Ernst RK, Rotjan RD, Kagan JC (2021) Deep-sea microbes as tools to refine the rules of innate immune pattern recognition. Science Immunol. 12;6(57):eabe0531. PMID: 33712473
Ernst O, Khan MM, Oyler BL, Yoon SH, Sun J, Lin FY, Manes NP, MacKerell AD Jr, Fraser IDC, Ernst RK, Goodlett DR, Nita-Lazar A (2021) Species-Specific Endotoxin Stimulus Determines Toll-Like Receptor 4- and Caspase 11-Mediated Pathway Activation Characteristics. mSystems. Aug 3:e0030621. PMID: 34342534
Adamiak JW, Jhawar V, Bonifay V, Chandler CE, Leus IV, Ernst RK, Schweizer HP, Zgurskaya HI. (2021) Loss of RND-type multidrug efflux pumps triggers iron starvation and lipid A modifications in Pseudomonas aeruginosa. Antimicrob Agents Chemother. Jul 12:AAC0059221. PMID: 34252310
Chattagul S, Khan MM, Scott AJ, Nita-Lazar A, Ernst RK, Goodlett DR, Sermswan RW. (2021) Transcriptomics Analysis Uncovers Transient Ceftazidime Tolerance in BurkholderiaBiofilms. ACS Infect Dis. 7(8):2324-2336. PMID: 34138549
Ahn D, Bhushan G, McConville TH, Annavajhala MK, Soni RK, Wong Fok Lung T, Hofstaedter CE, Shah SS, Chong AM, Castano VG, Ernst RK, Uhlemann AC, Prince A (2021) An acquired acyltransferase promotes Klebsiella pneumoniaeST258 respiratory infection. Cell Rep. 35(9):109196. PMID: 34077733
Nanishi E, Borriello F, O'Meara TR, McGrath ME, Saito Y, Haupt RE, Seo HS, van Haren SD, Brook B, Chen J, Diray-Arce J, Doss-Gollin S, Leon M, Chew K, Menon M, Song K, Xu AZ, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Sherman AC, Baden LR, Ernst RK, Dillen C, Weston SM, Johnson RM, Hammond HL, Mayer R, Burke A, Bottazzi ME, Hotez PJ, Strych U, Chang A, Yu J, Barouch DH, Dhe-Paganon S, Zanoni I, Ozonoff A, Frieman MB, Levy O, Dowling DJ (2021) Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity. bioRxiv. May 21:2021.05.20.444848. PMID: 34031655
Guillotte ML, Chandler CE, Verhoeve VI, Gillespie JJ, Driscoll TP, Rahman MS, Ernst RK, Azad AF (2021) Lipid A Structural Divergence in Rickettsia Pathogens. mSphere. 6(3):e00184-21. PMID: 33952661
Cross AS, Opal SM, Palardy JE, Shridhar S, Baliban SM, Scott AJ, Chahin AB, Ernst RK. (2021) A pilot study of an anti-endotoxin Ig-enriched bovine colostrum to prevent experimental sepsis. Innate Immun. 27(3):266-274. PMID: 33858243
Band VI, Satola SW, Smith RD, Hufnagel DA, Bower C, Conley AB, Rishishwar L, Dale SE, Hardy DJ, Vargas RL, Dumyati G, Kainer MA, Phipps EC, Pierce R, Wilson LE, Sorensen M, Nilsson E, Jordan IK, Burd EM, Farley MM, Jacob JT, Ernst RK, Weiss DS (2021) Colistin Heteroresistance Is Largely Undetected among Carbapenem-Resistant Enterobacterales in the United States. mBio. Jan 26;12(1):e02881-20. PMID: 33500343
Cetuk H, Anishkin A, Scott AJ, Rempe SB, Ernst RK, Sukharev S. (2021) Partitioning of Seven Different Classes of Antibiotics into LPS Monolayers Supports Three Different Permeation Mechanisms through the Outer Bacterial Membrane. Feb 2;37(4):1372-1385. Epub 2021 Jan 15. PMID: 33449700